The original McCarter, Off-Broadway, and Broadway casts included David Hyde Pierce, Kristine Nielsen, Sigourney Weaver and Billy Magnussen.

The play premiered at McCarter Theatre in Princeton, New Jersey in 2012, followed by an Off-Broadway production later the same year. assumed identities, the challenges of a woman growing older after successes in a career that seems to be ending, the hope and carelessness of youth, intrafamilial rivalries, and the possible loss of an ancestral home. Some of the show's elements were derived from works of Anton Chekhov, including several character names and sibling relationships, the play's setting in a country house (in Bucks County, Pennsylvania) with a vestigial cherry orchard, the performance of an 'avant-garde' play by one of the main characters (as in The Seagull), and the themes of old vs. They discuss their lives and loves, argue, and Masha threatens to sell the house. The story revolves around the relationships of three middle-aged single siblings, two of whom live together, and takes place during a visit by the third, Masha, who supports them. Vanya and Sonia and Masha and Spike is a comedy play written by Christopher Durang.

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